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Further support of this hypothesis comes from work in drosophila suggesting that overexpressing antioxidant genes specifically in the neurons of wildtype flies reduces the amount of time sleeping (Hill et al., 2018)

The molecule is small enough to cross the epidermal barrier to some degree, but reaching fibroblasts in the mid-to-deep dermis where the structural work happens requires either injection or a delivery mechanism that bypasses the barrier

Bjrklund G, Skalny AV, Rahman MM, Dadar M, Yassa HA, Aaseth J, Chirumbolo S, Skalnaya MG, Tinkov AA (2018a) Toxic metal(loid)-based pollutants and their possible role in autism spectrum disorder

Antioxidants (Basel) 10, 1129