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Leg ulcers in cirrhosis patients result from necrotic tissue due to hypoxia and venous reflux obstruction, with similar occurrences in chronic venous insufficiency and diabetes (89, 90)

144 Glutathione (GSH), the tripeptide -glutamyl cysteinyl glycine (Figure 3), is considered the main intracellular low molecular weight antioxidant but is also a key determinant of redox signaling and xenobiotic metabolism and one of the most important ways of reducing power in the cell